9/21/2023 0 Comments What does sidechain mean![]() Results: Using a dataset of 18 proteins, we trained a neural network for the prediction of methyl-bearing side-chain dynamics as described by the methyl side-chain generalized order parameters ( S 2) inferred from NMR data. In particular, quantitative description of side-chain dynamics would allow us to understand the role of side-chain flexibility in different functional processes, such as protein–ligand and protein–protein interactions. Thus, prediction of protein flexibility from sequence or structural characteristics would assist in comprehension of the ways dynamics is linked to function, and would be important in protein modeling and design. ![]() Motivation: Protein dynamics is believed to influence protein function through a variety of mechanisms, some of which are not fully understood.
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